Coffee & Alzheimer’s Disease – What’s the Verdict?

By: Simon Spichak

With all the seemingly contradictory headlines, it is hard to tell whether coffee is good or bad for you. This article explores the issue.

There’s nothing like the first cup of coffee in the morning to jumpstart the day. Because the average American drinks more than three cups of coffee every day, researchers were curious whether this caffeinated drink had any effect on our brain health.

Every month there’s an article in the news connecting coffee to cognition. Sometimes the studies featured in these articles indicate that coffee staves off dementia, but other studies suggest negative effects. Why does the research seem to yield conflicting results — and how much coffee should you be drinking?

Does Coffee Affect Brain Health?

Maybe! Plenty of recent studies suggest a relationship between coffee consumption and brain health. Earlier this year, an observational study of 398,646 participants linked high levels of coffee consumption with a smaller overall brain volume. 

In that study, the risk of dementia was highest in individuals drinking more than six cups, and in support of moderation, it was found to be lowest among those drinking one to two cups. However, this observational study was not able to collect complete dietary information for all participants. Unhealthy diets are also linked to dementia, so food consumption  alongside coffee intake could skew the results.

A 2018 study pooled several large studies together, forming an impressive sample of 328,885 people. Results from this study did not find any notable association at all between the risk of developing Alzheimer’s and coffee consumption.  

The Final Verdict on Coffee

For new Alzheimer’s treatments, scientists run randomized, blinded trials. This is impossible to do for coffee drinkers because most Americans drink coffee every day. Instead, many of these studies look at large populations to see whether people who drink a certain amount of coffee are more likely to develop Alzheimer’s than non-drinkers. These studies can’t provide a clear verdict because many variables are not measured: Are people taking their coffee with cream or milk? Are they drinking an espresso or a latte?  How strong do they enjoy their brew? 

To make matters even more intricate, recent research also suggests that certain genetic traits are linked to coffee metabolism and drinking more coffee; it may be difficult to separate out this genetic factor when considering the impact of coffee consumption on the brain.

Ultimately these studies provide scientists with a few clues; none have definitively  shown that drinking a certain amount of coffee will affect brain health. 

So, what have we learned? Firstly, that articles proclaiming some clear, definitive link between a daily habit like coffee and your dementia risk are likely oversimplifying the issue; and secondly, that if you are looking to improve your brain health, turn your attention from your caffeine habit to better known lifestyle opportunities: like a healthy diet, exercise, and good sleep to name a few.


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Melissa Belardo, APRN

Clinical Investigator

Melissa Belardo, is a certified family nurse practitioner (FNP-BC), joins K2 Medical Research with more than a decade of clinical experience. She has served as an investigator in over 20 trials. Prior to clinical research, she held roles in gastroenterology, hepatology, and nurse education.

Melissa’s academic background includes a Bachelor of Science in Nursing from Adventist University, followed by a master’s degree in Family Nurse Practitioner from Georgetown University.

Melissa is a native of the US Virgin Islands’ and is fluent in both English and Spanish; Melissa has lived in central Florida for the past twenty years. When she’s not at work, you can find her volunteering at her local church and spending time with family.