Indigenous Amazonians Don’t Develop Alzheimer’s – Why?

Is there any surefire way to prevent Alzheimer’s diease? Data published in The Lancet found that as many as 40 percent of dementia cases are preventable by addressing modifiable, lifestyle-related risk factors, such as high blood pressure and obesity. And yet, there are some people who, even though they follow every science-backed suggestion about lowering their risk, still develop this mysterious disease. Scientists are working to understand whether there are any changes we can make to our lifestyles that offer us extra protection.

One place they’re looking for clues: the jungles of the Amazon. Some populations of people seem to get Alzheimer’s disease very rarely if at all. One of these populations, the Tsimané people, lives in the Bolivian Amazon. Scientists recently discovered that they have the lowest known rates of brain — and heart — disease of any community on Earth. 

What is it about this group that protects brain health? Scientists believe, since their lifestyle is so very different from most other cultures, that the protective factor could be a matter of “nurture” over “nature.” For example, this community doesn’t use modern technology. They don’t eat mass-produced foods, and don’t experience as many of the health risks related to living in the “developed” world. 

For the last two decades, researchers from the University of Southern California have studied Bolivia’s Tsimané community. Here’s what they’ve learned so far.


Why don’t Tsimané develop Alzheimer’s

Dr. Andrei Irimia, an assistant professor at the University of Southern California who studies the Tsimané, told Being Patient in a recent Live Talk that this group isn’t exposed to various risk factors linked to industrialization: Air pollution, junk food, and a sedentary lifestyle

[The Tsimané] have a lot of very high levels of physical activity, such that their lifestyle is quite different from the sedentary lifestyle here in the United States or elsewhere in the world,” Irimia said. In addition, their diet is extremely healthy. It is high in fruits, vegetables, fiber, fish, and lean game meat from animals hunted in the forest.

A 2022 study published in the journal Alzheimer’s and Dementia found that 7.7 percent of Tsimané elders over 60 had signs of mild cognitive impairment, compared to 12 to 18 percent for Americans in the U.S. 

While mild cognitive impairment is usually a risk factor for developing Alzheimer’s, it rarely progressed in the Tsimané. After studying 435 people, the researchers only found five total dementia cases.

“Their dementia is not usually of the Alzheimer’s type,” Irimia said. “It seems to be a novel type of dementia syndrome that is new to science.”


Lessons from the Tsimané and other Indigenous groups

According to Irimia, studying remote populations like the Tsimané is challenging. In this case, advanced diagnostic tests like PET amyloid scans aren’t available in Bolivia, where the Tsimané are being studied. That means it is impossible to tell whether there is a buildup of amyloid plaques, which are linked to Alzheimer’s. The researchers also don’t have access to post-mortem samples. So, scientists don’t have all the pieces to this puzzle.

Large-scale studies so far haven’t been able to definitively link some of these lifestyle factors, like diet or exercise, to meaningfully reduce the risk of developing Alzheimer’s or dementia. “The brain functions optimally when there is an optimal level of food intake and exercise,” Irimia said. Too little exercise or improper nutrition, as well as too much food intake, is linked to brain shrinkage across different conditions. 

Perhaps the Tsimané can help us find the sweet spot.


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Melissa Belardo, APRN

Clinical Investigator

Melissa Belardo, is a certified family nurse practitioner (FNP-BC), joins K2 Medical Research with more than a decade of clinical experience. She has served as an investigator in over 20 trials. Prior to clinical research, she held roles in gastroenterology, hepatology, and nurse education.

Melissa’s academic background includes a Bachelor of Science in Nursing from Adventist University, followed by a master’s degree in Family Nurse Practitioner from Georgetown University.

Melissa is a native of the US Virgin Islands’ and is fluent in both English and Spanish; Melissa has lived in central Florida for the past twenty years. When she’s not at work, you can find her volunteering at her local church and spending time with family.